<p>The present invention discloses simian-human hepatitis A virus chimeric genomes which encode a hepatitis A virus having a chimeric 2C protein. The invention further discloses the use of these viruses or the nucleic acid sequence encoding them as vaccines.</p>
申请公布号
EP0904379(A2)
申请公布日期
1999.03.31
申请号
EP19970923424
申请日期
1997.04.18
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
RAYCHAUDHURI, GOPA;EMERSON, SUZANNE, U.;PURCELL, ROBERT, H.
