| 摘要 |
Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating, or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS. These compounds are of the formula <IMAGE> (1) including the N-terminal acylated and/or C-terminal amidated or esterified forms thereof wherein each of A1, A5, A10, A14 and A20 is independently Ala, Gly or Ser; each of A2, A4, A7, A9, A11, A12, A13, A16, A17, A19 and A22 is independently a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met; each of A3 and A8 is independently a neutral polar amino acid selected from Asn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu, Val, Phe and Met; each of A6, A18 and A21 is independently a basic amino acid selected from Arg, Lys, and Har; and wherein A15 is Trp or a basic amino acid selected from Lys, Arg and Har; wherein n is an integer of 1-6; and the antimicrobial or LPS-binding fragments thereof. Recombinant materials for the production of these peptides are also disclosed.
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