发明名称 |
Method for stabilizing pranoprofen and stable liquid preparation of pranaprofen |
摘要 |
A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparation of pranoprofen, comprising pranoprofen and an antioxidant. According to the present invention, the decomposition of pranoprofen in an aqueous solution of pranoprofen is remarkably suppressed. In particular, pranoprofen becomes stable to light, thus permitting long-term preservation of an aqueous solution, specifically a liquid preparation, of pranoprofen.
|
申请公布号 |
US5889030(A) |
申请公布日期 |
1999.03.30 |
申请号 |
US19970873924 |
申请日期 |
1997.06.12 |
申请人 |
SENJU PHARMACEUTICAL CO., LTD.;YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
DOI, KOJI;SAWA, HISAKO;OZAKI, YOSHIE;KIMURA, YOSHIYUKI |
分类号 |
A61K31/436;A61K9/00;A61K9/08;A61K31/435;A61K47/02;A61K47/08;A61K47/10;A61K47/16;A61K47/18;A61K47/22;A61P29/00;(IPC1-7):A61K31/44 |
主分类号 |
A61K31/436 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|