发明名称 |
Regulation of vascular smooth muscle cell heme oxygenase-1 |
摘要 |
The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.
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申请公布号 |
US5888982(A) |
申请公布日期 |
1999.03.30 |
申请号 |
US19970831475 |
申请日期 |
1997.03.31 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
PERRELLA, MARK A.;LEE, MU-EN |
分类号 |
A61K38/00;A61P29/00;C12N9/02;C12Q1/26;C12Q1/68;(IPC1-7):A61K39/395;A61K48/00;C12Q1/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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