5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS

摘要

The present invention provides novel 5-(1-fluorovinyl)-1H-pyrimidine-2,4-dione derivatives of formula (I) which are useful as antineoplastic agents by themselves or in conjunctive therapy with the antineoplastic agent 5-fluorouracil. In said formula, R1 and R2 are each independently hydrogen, C1-C4 alkyl, or a phenyl group unsubstituted or substituted with from 1 to 3 substituents, wherein each substituents is selected from the group consisting of C1-C4 alkyl and C1-C4 alkoxy; and R3 is hydrogen, ribose, 2'-deoxyribose or arabinose.