发明名称 |
Composition and method for enhancing paracellular transport across cell layers |
摘要 |
A composition and method for enhancing paracellular transport across cell layers in an animal comprising an antisense oligonucleotide hybridizable with a region of the messenger RNA coding for the protein occludin which, when hybridized to the occludin mRNA, interferes with its translation such that occludin function is disrupted and paracellular permeability is increased across an epithelial cell layer or and endothelial cell layer in an animal. |
申请公布号 |
ZA9808624(B) |
申请公布日期 |
1999.03.30 |
申请号 |
ZA19980008624 |
申请日期 |
1998.09.21 |
申请人 |
ELAN CORPORATION, PLC. |
发明人 |
GERARD CAGNEY;DANIEL JOSEPH O'MAHONY |
分类号 |
A61K;A61K38/00;A61K47/36;A61K48/00;C07H;C07H21/00;C12N15/113 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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