发明名称 |
Genetically modified tumor-targeted bacteria with reduced virulence |
摘要 |
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as an genetic modification in a biosynthetic pathway gene such as the purl gene. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors. |
申请公布号 |
AU9380798(A) |
申请公布日期 |
1999.03.29 |
申请号 |
AU19980093807 |
申请日期 |
1998.09.09 |
申请人 |
VION PHARMACEUTICALS, INC.;YALE UNIVERSITY |
发明人 |
DAVID BERMUDES;KENNETH B. LOW;MARTINA ITTENSOHN |
分类号 |
C12N15/09;A61K35/74;A61K38/00;A61K39/00;A61K39/02;A61K39/112;A61K48/00;A61P35/00;C07K14/255;C12N1/21;C12P19/28;C12R1/42 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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