| 摘要 |
Compounds represented by general formula (I) or salts thereof, which exhibit an antihistaminic activity and an eosinochemotaxis inhibitory activity and are therefore useful as preventive and therapeutic agents for asthma, allergic conjunctivitis, allergic rhinitis, urticaria, atopic dermatitis and so on. In said formula, A is a (substituted) homocycle or nitrogenous heterocycle; D and E are each O or S; and one of R1 and R2 is a group represented by general formula (II), ¢wherein Ar1 and Ar2 are each a (substituted) aromatic group or they together with the carbon atom adjacent to them may form a (substituted) fused-ring group; B is a (substituted) nitrogenous heterocycle; X and Y are each a bond, O, S(O)p (wherein p is an integer of 0 to 2), NR4 (wherein R4 is H or lower alkyl) or a divalent (substituted) linear lower hydrocarbon group optionally interrupted by a heteroatom; and R3 is H, (substituted) hydroxyl or (esterified) carboxyl!, and the other of them is H, cyano or a (substituted) hydrocarbon group.
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