发明名称 |
CHEMICAL MODIFICATION OF DNA USING PEPTIDE NUCLEIC ACID CONJUGATES |
摘要 |
Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to monitoring plasmid biodistribution, promote nuclear localization, induce transcriptional activation, lyse the endosomal compartment and facilitate transfection. Theses complexes increase the efficiency of expression of a particular gene.
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申请公布号 |
CA2303908(A1) |
申请公布日期 |
1999.03.25 |
申请号 |
CA19982303908 |
申请日期 |
1998.09.18 |
申请人 |
ISIS PHARMACEUTICALS;GENE THERAPY SYSTEMS, INC. |
发明人 |
FELGNER, PHILIP L.;ZELPHATI, OLIVER;BENNETT, C. FRANK |
分类号 |
C12N15/09;A61K48/00;A61P43/00;C07K14/00;C07K14/035;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N13/00;C12N15/65;C12N15/67;C12Q1/68;(IPC1-7):A01N43/04;A01N63/00;C12N5/00 |
主分类号 |
C12N15/09 |
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