发明名称 |
MACROPHAGE DERIVED CHEMOKINE (MDC) AS AN ANTI-VIRAL AGENT FOR THE TREATMENT AND PREVENTION OF LENTIVIRUS INFECTIONS |
摘要 |
The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lentivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
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申请公布号 |
CA2303397(A1) |
申请公布日期 |
1999.03.25 |
申请号 |
CA19982303397 |
申请日期 |
1998.09.16 |
申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE;AKZO NOBEL N.V. |
发明人 |
DEVICO, ANTHONY L.;PAL, RANAJIT;GALLO, ROBERT C.;MARKHAM, PHILLIP D.;GARZINO-DEMO, ALFREDO |
分类号 |
G01N33/569;A61K38/00;A61K48/00;A61P31/18;C07K14/52;C12N5/10;C12N15/00;C12P21/02;C12Q1/68;(IPC1-7):C12N15/19;C12N15/66 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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