摘要 |
Disclosed is a beadlet comprising (i) a hydrophobic long chain fatty acid or ester material; (ii) a surfactant; and (iii) a therapeutic agent, which in admixture form a solid solution at room temperature. The hydrophobic material preferably has a melting point of about 40 to about 100 DEG C, and is most preferably glyceryl behenate. The surfactant is preferably a polyglycolyzed glyceride, polyoxyethylene sorbate, ethylene or propylene block copolymer or combinations thereof, and is most preferably polyoxyethylene 20 sorbitan monolaurate. |
申请人 |
SHIRE LABORATORIES, INC. |
发明人 |
BURNSIDE, BETH, A.;MC GUINNESS, CHARLOTTE, M.;RUDNIC, EDWARD, M.;COUCH, RICHARD, A.;GUO, XIAODI;TUSTIAN, ALEXANDER, K. |