| 摘要 |
<p>The present invention provides novel method for detecting a genetic predisposition for diabetic nephropathy. In one aspect, the method comprises comparing a nucleic acid encoding for normal human angiotensin type II receptor (AT1) with that found in an individual to be tested. In other embodiments, the method comprises detecting a nucleic acid sequence within a span of about 20 centimorgans around the human ATI locus on chromosome 3q, which has been found to be genetically linked with the occurrence of diabetic nephropathy. In a further preferred embodiment, the method comprises comparing a nucleic acid encoding for normal human CD10/neutral endopeptidase 24.11 gene, with that found in an individual to be tested, wherein differences in sequence indicate a predisposition for diabetic nephropathy. In another aspect, the present invention also provides a novel method for detecting genetic linkage for diabetic nephropathy which comprises genetic analysis of nucleic acid from sibling-pairs who are concordant for type I diabetes, but are discordant for diabetic nephropathy pathology.</p> |
