摘要 |
PROBLEM TO BE SOLVED: To obtain the subject fine granules which prevent the retardation of elution with time and is particularly useful for quinolone antibacterial agents and anti-inflammatory analgesics by formulating a medicine, a nucleous, a sucrose fatty acid ester, a polyethylene glycol, a disintegrant and a fluidization agent. SOLUTION: The objective fine granules are obtained by forming particles by means of adding (B) preferably a β-lactam-based antibacterial agent or a central nervous system medicine and the like, particularly a medicine of a pyridone carboxylic acid of the formula (R<1> is H and the like; R<2> is a cycloalkyl and the like; R<3> is an alkyl and the like, A and B are each N and the like), (C) a sucrose fatty acid ester with an HLB value of 3-15 and (D) a disintegrant under heating to the nuclei composed of particles preferably granulated at a size of 50-400 μm, coating the surface of the particles with (E) a copolymer of polyethyleneglycol and/or polyoxyethylenepolyoxypropylene under further heating and then, after cooling, adding (F) a fluidization agent such as hydrous silicon dioxide and the like. |