| 摘要 |
PROBLEM TO BE SOLVED: To obtain a cell growth inhibitor having cell growth-inhibiting activities based on apoptosis induction, capable of selectively inhibiting only growth of morbid cell without affecting ambient normal cells and useful for treatment of cancer such as leukemia by including abrin. SOLUTION: This cell growth inhibitor contains 0.1-10% abrin, which is a strongly toxic lectin including abrin-a having 63,000 molecular weight or the like as an active ingredient. The abrin is prepared, for example, by pulverizing seeds of Abrus precatorius in the presence of liquid nitrogen, degreasing the pulverized seeds of Abrus precatorius, extracting the degreased seeds of the Abrus precatorius with deionized water, salting out the extract with ammonium sulfate, washing the salted out extract, and fractionating the washed extract by a column chromatography, purifying the fractionated extract by a gel filtration and an ion-exchanging, and concentrating the purified extract. The daily dose is normally 0.01-10 mg/kg and the inhibitor is parenterally administered. |
