| 摘要 |
PCT No. PCT/JP95/00085 Sec. 371 Date Jul. 23, 1996 Sec. 102(e) Date Jul. 23, 1996 PCT Filed Jan. 25, 1995 PCT Pub. No. WO95/20388 PCT Pub. Date Aug. 3, 1995An anti-HIV agent, an anti-HIV effect-potentiating agent and a prophylactic and remedial agent for AIDS each comprising, as an active ingredient, a vitamin B1 derivative such as thiamine disulfide, bisbentiamine, bisbutytiamine, bisibutiamine, alitiamine, fursultiamine or octotiamine, or the salt thereof. The agents according to the present invention are useful for prophylaxis of and treatment for AIDS because they have a very preferable nature that they inhibit the growth of HIV without killing cells against primarily infected cells, but exhibit both cell-killing effect and HIV-killing effect at the same time against persistent-production cells which have come to persistently produce HIV.
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