发明名称 |
Metal complexes of polyamino acids, and their utilization in diagnostic imaging |
摘要 |
PCT No. PCT/FR96/00992 Sec. 371 Date Dec. 29, 1997 Sec. 102(e) Date Dec. 29, 1997 PCT Filed Jun. 25, 1996 PCT Pub. No. WO97/01359 PCT Pub. Date Jan. 16, 1997The invention concerns gadolinium complexes of formula: <IMAGE> I in which R represents a group of formula: <IMAGE> in which X is Br or I; R1 is H or optionally hydroxylated alkyl; R2 is hydroxylated alkyl; or alternatively R1 is H and R2 is a group of formula: <IMAGE> A X being as defined above, and R'1 and R'2 being as defined for R1 and R2 excepted that they do not represent A, provided that -CO-NR1R2 or -CO-NR'1R'2 comprises at least 2 hydroxyl groups, and M represents H or the cation of an inorganic or organic base.
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申请公布号 |
US5886158(A) |
申请公布日期 |
1999.03.23 |
申请号 |
US19970981022 |
申请日期 |
1997.12.29 |
申请人 |
GUERBET S.A. |
发明人 |
MEYER, DOMINIQUE;ROUSSEAUX, OLIVIER;SCHAEFER, MICHEL;SIMONOT, CHRISTIAN |
分类号 |
A61K49/00;A61K49/04;A61K49/08;C07D257/02;(IPC1-7):C07F5/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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