发明名称 |
Screening method for determining individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53 |
摘要 |
The present invention relates to a screening method to identify individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53; which comprises the steps of: a) obtaining a biological sample from said patients; and b) determining the presence of p53pro or p53arg wildtype alleles in said sample; wherein the allele pattern of patients selected from the group consisting of p53pro/p53pro, p53arg/p53arg and p53pro/p53arg are indicative of a risk factor for developing disease associated with different polymorphic forms of wildtype p53. Notably, individuals who are p53arg/arg are at greater risk of developing pathologies associated with human papillomavirus infections, including cervical cancer. |
申请公布号 |
AU8969098(A) |
申请公布日期 |
1999.03.22 |
申请号 |
AU19980089690 |
申请日期 |
1998.08.31 |
申请人 |
MCGILL UNIVERSITY;IMPERIAL CANCER RESEARCH TECHNOLOGY (ICRT);INTERNATIONAL CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY |
发明人 |
GREG J. MATLASHEWSKI;LAWRENCE BANKS;ALAN STOREY |
分类号 |
G01N33/50;C12N15/09;C12Q1/68;C12Q1/70;G01N33/15;G01N33/569;G01N33/574 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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