Poly(adp-ribose) polymerase (parp) inhibitors, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage

摘要

This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula:or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, whereinY is alkylhalo, alkyl-CO-G, COG, a direct bond, C=O, O, NR11, or CR8;G is NR11R16, OR9, SR9, or R10;Z is O, S, or NR11;X is NR16, O, S, CR12R13, C=O, a bond, -CR12=CR13-, -C(R12R13)C(R14R15)-, or;Rhd 1, R2, R3, R4, R5, R6, R7, R8, R10, R12, R13, R14, or R15 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, nitro, nitroso, carboxy, or aralkyl;R9 is hydrogen, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl;R11 or R16 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl.