| 摘要 |
Novel epoxysuccinamide derivatives represented by the general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R<1> and R<3> are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; R<2> is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or a hetericyclic -alkyl group; X is -O- or -NR<4>- (wherein R<4> is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or a heterocyclic-alkyl group; Y<1> is OR<5>, SR<6>, or NR<7>R<8> (wherein each of R<5>, R<6> and R<7> is hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or a heterocyclic-alkyl group, and R<8> is the same as defined for R<4>); and Y<2> is hydrogen or alkyl, or alternatively Y<1> and Y<2> can be combined to form =O, =S, =N-R<9>, or =N-OR<10> (wherein each of R<9> and R<10> is the same as defined for R<4>), provided that each of the alkyl, aryl and heterocyclic groups defined for R<5> to R<10> can have one or more specific substituents and that each of the group defined for R<1> to R<10> and Y<2> is specificed in the number of carbon atoms. <CHEM> |
