NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS
摘要
<p>This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.</p>
申请公布号
LV12167(B)
申请公布日期
1999.03.20
申请号
LV19980000104
申请日期
1998.07.07
申请人
DUPONT PHARMACEUTICALS COMPANY
发明人
XUE,CHU-BIAO;CHERNEY,ROBERT JOSEPH;DECICCO,CARL PETER;DEGRADO,WILLIAM, FRANK;HE,XIAOHUA;HODGE,CARL NICHOLAS;JACOBSON,IRINA CIPORA;MAGOLDA,RONALD LOUIS;ARNER,ELIZABETH CATHERINE;DUAN,JINGWU;NELSON,DAVID J.