DERIVATIVES OF PYRIDOPYRIMIDINE, THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION, A METHOD OF TREATMENT

摘要

FIELD: organic chemistry, medicine. SUBSTANCE: invention describes new derivatives of pyridopyrimidine of the formula (A) where means -(CH2)m- (m = 0, 1 or 2); n = 1-3; R means hydrogen atom; C1-6-alkyl-group that can be optionally substituted with one of substituents taken from quinolyl or indolyl; phenyl group that can be optionally substituted with at least one C1-6-alkoxy-group; or phenyl-C1-3-alkyl-group that can be optionally substituted with at least one substituent taken from C1-6-alkoxy- and C1-6-alkylthio-group; R means hydrogen atom or C1-6-alkyl-group; R means phenyl or naphthyl group that can be optionally substituted with at least one substituent taken from C1-6-alkyl, C1-6-alkoxy-, C1-6-alkylenedioxy-group, halogen atom, nitro-, cyano-group, phenyl, C3-7-cycloalkyl; pyridyl that can be optionally substituted with C1-6-alkyl; thienyl that can be optionally substituted with C1-6-alkyl; quinolyl that can be optionally substituted with oxo-group or hydroxyl-group; quinolonyl; benzofuryl or benzothienyl that can be optionally substituted with C1-6-alkyl; R means a group -COO-COOR where R means hydrogen atom; C1-6-alkyl group optionally substituted with at least one substituent taken from C3-7-cycloalkyl-group, quinolyl-group, carboxyl-group, cyano- and phenyl-group; or C3-7-cycloalkyl; or a group -COA-R7R where R and R mean independently hydrogen atom or C1-6-alkyl group; R means hydrogen atom; C1-6-alkyl group or phenyl-group that can be optionally substituted with C1-6-alkylenedioxy-group, or its salt. Invention describes also a method of synthesis of compounds of the formula (A), pharmaceutical compositions based on compound of the formula (A) and a method of an antagonistic effect on endothelial receptors in treatment of patients with renal failure, myocardium i