发明名称 |
SYNERGISTIC EFFECTS OF OP/BMP MORPHOGENS AND GDNF/NGF NEUROTROPHIC FACTORS |
摘要 |
A synergistic effect of OP/BMP morphogens in combination with GDNF/NGF neurotrophic factors in promoting the survival or growth, or inhibiting the death or degeneration, of mammalian cells, particularly neural cells, which express OP/BMP-activated serine/threonine kinase receptors and GDNF/NGF-activated tyrosine kinase receptors, is disclosed. Also disclosed are new methods for the in vivo and in vitro treatment of such cells, including in vivo treatments for mammals afflicted with, or at imminent risk of, damage or injury to such cells, as well as new pharmaceutical preparations for such in vivo and in vitro treatments.
|
申请公布号 |
WO9912560(A1) |
申请公布日期 |
1999.03.18 |
申请号 |
WO1998US18772 |
申请日期 |
1998.09.09 |
申请人 |
CREATIVE BIOMOLECULES, INC.;RUEGER, DAVID, C.;CHARETTE, MARC, F.;EBENDAL, TED |
发明人 |
RUEGER, DAVID, C.;CHARETTE, MARC, F.;EBENDAL, TED |
分类号 |
A61K38/22;A61K38/18;A61P25/00;A61P43/00;(IPC1-7):A61K38/18;C12N5/06;C12N5/08 |
主分类号 |
A61K38/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|