HLA-DR Antigen-Gen, dessen Nukleotidsequenz und Verwendung
摘要
<p>We have found a novel subtype DRw14c and sequenced the nucleotide sequence thereof. DRw14 associated genes can be genetically typed at the DNA level using DRB1-14c sequence specific oligonucleotide probes such as F142 and F144 of the invention. The present invention overcomes the disadvantages of serological typing and provides a reagent that determines a type of a HLA-DR antigen. More specifically, the invention provides an oligonucleotide probe capable of identifying subtypes of a HLA-DR antigen precisely and a reagent containing the oligonucleotide probe. Furthermore, the invention provides a method of detecting a novel HLA-DR antigen.</p>
申请公布号
DE69130845(D1)
申请公布日期
1999.03.18
申请号
DE1991630845
申请日期
1991.08.20
申请人
MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP;THE KITASATO INSTITUTE, TOKIO/TOKYO, JP
发明人
OBATA, FIUMIYA, SAGAMIHARA-SHI, KANAGAWA-KEN, JP;KASHIWAGI, NOBORU, SHINJUKU-KU, TOKYO, JP