SUBSTITUTED 2-PYRROLIDINONE ACTIVATORS OF PKC

摘要

Compounds of formula (I) wherein R1 and R2 are each independently (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, (C3-C8)cycloalkyl(C1-C15)alkenyl, (C3-C8)cycloalkyl(C1-C15)alkynyl, (C1-C15)alkoxy, (C1-C15)alkanoyl, (C1-C15)alkanoyloxy, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl(C2-C15)alkenyl, heteroaryl(C2-C15)alkenyl, aryl(C2-C15)alkynyl, heteroaryl(C2-C15)alkynyl, aryl(C1-C15)alkoxy, heteroaryl(C1-C15)alkoxy, aryl(C1-C15)alkanoyl, heteroaryl(C1-C15)alkanoyl, aryl(C1-C15)alkanoyloxy, or heteroaryl(C1-C15)alkanoyloxy; wherein any R<1> or R<2> is optionally substituted with one or more substituents and their pharmaceutically acceptable salts, are PKC activators and are useful for treating diseases, such as, for example, cancer. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), processes for preparing compounds of formula (I), and intermediates useful for preparing compounds of formula (I).