FACTORS VII FRAGMENTS AND ANALOGS THEREOF AND THEIR USE IN THE TREATMENT OF BLOOD CLOTTING DISORDERS

摘要

This invention provides a compound which is capable of interacting with the internal receptor in the catalytic domain of FIXa or FX defined by the residues Ile?290, Ala291, Asp292, Tyr293, Thr294, Glu374¿, and Phe378 in FIXa and Leu?300, Pro301, Glu302, Trp305, Ala306, Lys385¿ and Phe389 in FXa or the ligand defined by residues Cys?95 to Cys99¿ in FIXa or Cys?96 to Cys100¿ in FXa to prevent the formation of a functional FVIIIa/FIXa complex or FXa/FV complex respectively.