DIAGNOSTIC AND THERAPEUTIC ALKYLENEDIAMINE COMPOUNDS AND PROCESS

摘要

Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by formula (I), wherein 1, m and n can be the same or different and are an integer of 1 to 6; X, Y and Z can be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C1-C6)alkoxy, N-alkyl, (C2-C6)acyloxy, N-alkylene, -SH, -SR, wherein R is from the same group as R1 and R2 and can be the same or different than R1 and R2, amino, nitro, cyano, hydroxy, C(=O)OR6, -C(=O)NR5R4, NR3R2, or S(=O)kR1, wherein k is 1 or 2, and R1 to R6 are independently hydrogen or (C1-C6)alkyl; R1 and R2 can be the same or different and are hydrogen, (C1-C6)alkyl, hydroxyalkyl or mercaptoalkyl, -C(=O)OR1, cyano, (C1-C6)alkenyl, (C2-C6)alkynyl, or 1,2,4-oxadiazol-5-yl optionally substituted at the 3-position by W wherein any (C1-C6)alkyl, (C1-C6)alkanoyl, (C2-C6)alkenyl or (C2-C6)alkynyl(C1-C6)alkyl, hydroxy(C1-C6)alkyl or mercapto(C1-C6)alkyl and optionally can be substituted by 1, 2 or 3 Z; W is (C1-C6)alkyl or phenyl, optionally substituted by 1, 2 or 3 Z. phi is phenyl, naphthyl, thienyl or pyridinyl.