STEREOISOMERIC INDOLE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND USE THEREOF

摘要

Novel stereoisomeric indole compounds represented by general formula (1), wherein Y is (2) or (3), (wherein * represents the position of an asymmetric carbon atom), [wherein X is C1-C5 alkyl optionally substituted with OH, carboxyl, amino, methylthio, mercapto, guanidyl, imidazolyl or benzyl; and R1 and R2 are each independently H, alkyl, aralkyl, cycloalkyl or aryl]; and R is H, alkyl, aralkyl, cycloalkyl, aryl, monovalent metal, amine or ammonium). The compounds can be prepared by condensing tryptophan with a stereoisomeric alpha -amino acid or carboxylic acid to form an amide and subjecting the amide to oxidative cyclization to form an oxazole ring at once. The compounds exhibit physiological activities such as inhibitory activity against lipid peroxidation, and can be therefore utilized in the form of lipid peroxidation inhibitors containing the same as the active ingredient.