发明名称 |
Arginine mimic derivatives as enzyme inhibitors |
摘要 |
The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described.
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申请公布号 |
US5883107(A) |
申请公布日期 |
1999.03.16 |
申请号 |
US19950487611 |
申请日期 |
1995.06.07 |
申请人 |
CORVAS INTERNATIONAL, INC. |
发明人 |
LEVY, ODILE ESTHER;TAMURA, SUSAN YOSHIKO;NUTT, RUTH FOELSCHE;RIPKA, WILLIAM CHARLES |
分类号 |
A61K38/00;A61P7/02;C07K5/06;C07K5/072;C07K5/078;(IPC1-7):A61K31/435;A61K31/445;C07D401/12;C07D453/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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