发明名称 |
Heterodimeric T lymphocyte receptor |
摘要 |
Disclosed is a heterodimeric T lymphocyte receptor subunit. The subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor subunit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes. T cell receptor subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
|
申请公布号 |
US5882945(A) |
申请公布日期 |
1999.03.16 |
申请号 |
US19940262827 |
申请日期 |
1994.06.21 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
SAITO, HARUO;KRANZ, DAVID M.;EISEN, HERMAN N.;TONEGAWA, SUSUMU |
分类号 |
A61K39/00;C07K14/725;(IPC1-7):G01N33/531;C07K16/28 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|