发明名称 |
NATAMYCIN RECOVERY |
摘要 |
A process for the recovery of high purity natamycin from fermentation broth by extraction with methanol is disclosed. In one embodiment the process comprises the steps: (1) adding methanol to a natamycin feed stream comprising at least 2g/L of solid suspended natamycin to form an extraction medium, and maintaining the extraction medium at a temperature of 0-25.degree.C, preferably not over l5.degree.C; (2) adjusting the pH of the extraction medium to 1.0 to 4.5 while maintaining the temperature at 0-25.degree.C for O.5 to 30 hours, but preferably not over O.5 hour when the temperature is l5-25.degree.C; (3) removing solids from the extraction medium to form an extraction liquor; (4) raising the pH of the extraction liquor to 6.0-9.0; and (5) recovering precipitated natamycin.
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申请公布号 |
CA2171712(C) |
申请公布日期 |
1999.03.16 |
申请号 |
CA19942171712 |
申请日期 |
1994.09.16 |
申请人 |
BIO-TECHNICAL RESOURCES L.P. |
发明人 |
OLSON, PHILLIP TERRY;REIMER, MICHAEL HENRY;MILLIS, JAMES R. |
分类号 |
C12P19/62;(IPC1-7):C12P19/62;C07H17/08 |
主分类号 |
C12P19/62 |
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