Method for influencing beta -lactam antibiotic production and for isolation of large quantities of ACV synthetase

摘要

Novel methods and compositions are provided for the enhanced production of beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase genes have been isolated and sequenced. Also methods are provided for the production of delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase using recombined DNA techniques.