| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound useful as anα1 A/1 L-adrenaline receptor agonist. SOLUTION: This new compound is shown by formula I [A is R<1> q (R<3> R<60> N)m (Z)(NR<2> )n ; (m) and (q) are each 0 or 1; Z is C=O or SO2 ; (n) is 1; X is NH, CH2 or OCH2 ; Y is 2-imidazoline, 2-oxazoline, 2-thiazoline or 4-imidazole; R<1> to R<3> and R<60> are each H, a lower alkyl, phenyl or the like; R<4> to R<7> are each H, a lower alkyl, CF3 , a lower alkoxy, halogen, phenyl, a lower alkenyl, hydroxyl, a lower alkylsulfonamido or the like], e.g. N-[(3-(4,5-dihydro-1H-imidazol-2- ylmethoxy)phenyl]methanesulfonamide. The compound of' formula I is obtained by reaction of a compound of formula II with 1,2-diaminoethane (in the case that A is R<1> SO2 NH, X is CH2 or OCH2 , Y is 2-imidazoline). This new compound is effective for such diseases as incontinence of urine, nasal congestion, priapism, depression, anxiety, dementia and senility.
|
