Human DNA sequence encoding a kidney ATP-dependent potassium channel

摘要

PCT No. PCT/US94/01210 Sec. 371 Date Aug. 9, 1995 Sec. 102(e) Date Aug. 9, 1995 PCT Filed Feb. 15, 1994 PCT Pub. No. WO94/19464 PCT Pub. Date Sep. 1, 1994The present invention comprises human DNA compositions encoding proteins that confer potassium channel activity to membranes or recipient cell lines. The DNA compositions include structural genes coding for the potassium channel proteins, expression and replication plasmids or vectors containing the structural genes and host cells expressing those genes. Methods of screening compounds for potassium channel modulating activity are also described.