Method for inhibiting H. pylori infection in mammalian tissue

摘要

A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I (NeuAc- alpha (2-3)-pGal- beta (1)-(-X-)m-(-Y-)n-)p-Z wherein X=a chemical bond or a group capable of linking the p galactose to either the linking group Y or the multivalent support Z; wherein the C1 glycosidic oxygen of galactose may be replaced by N, S or C; Y=a linking group; Z=a multivalent support; m=0 or 1; n=0 or 1; and p=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula II NeuAc- alpha (2-3)-pGal- beta (1)-A wherein A=a group capable of bonding to the p galactose; wherein the C1 glycosidic oxygen of galactose may be replaced by N, S or C.