发明名称 |
Adenoviral vectors for gene therapy containing deletions in the adenoviral genome |
摘要 |
Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.
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申请公布号 |
US5882877(A) |
申请公布日期 |
1999.03.16 |
申请号 |
US19970895194 |
申请日期 |
1997.07.16 |
申请人 |
GENZYME CORPORATION |
发明人 |
GREGORY, RICHARD J.;ARMENTANO, DONNA;COUTURE, LARRY A.;SMITH, ALAN E. |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/861;(IPC1-7):C12N15/00;C12N15/86 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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