| 摘要 |
<p>The present invention provides an immortalized insulin producing human β-cell which may be rendered glucose responsive by suitable bioengineering methods. The invention also provides a method for producing an immortalized glucose responsive insulin producing human β-cell comprising the steps of selecting an unregulated immortalized human insulin secreting β-cell, transfecting said selected cell line with elements for the genetic control of glucose responsiveness and proliferating said transfected β-cell accordingly.</p> |
