发明名称 POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURAL OR CARDIOVASCULAR TISSUE DAMAGE
摘要 This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of formula (I), or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein: Y is alkylhalo, alkyl-CO-G, COG, a direct bond, C=O, O, NR11, or CR8; G is NR11R16, OR9, SR9, or R10; Z is O, S or NR11; X is NR16, O, S, CR12R13, C=O, a bond, -CR12=CR13-, C(R12R13)C(R14R15)-, or R1, R2, R3, R4, R5, R6, R7, R8, R10, R12, R13, R14, or R15, are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, nitro, nitroso, carboxy, or aralkyl; R9 is hydrogen, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl; R11 or R16 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl.
申请公布号 CA2294133(A1) 申请公布日期 1999.03.11
申请号 CA19982294133 申请日期 1998.09.02
申请人 GUILFORD PHARMACEUTICALS INC. 发明人 LI, JIA-HE;ZHANG, JIE;MACLIN, KEITH M.;JACKSON, PAUL F.
分类号 C07D237/26;A61K9/08;A61K9/10;A61K9/107;A61K9/20;A61K9/48;A61K31/436;A61K31/4365;A61K31/4375;A61K31/4741;A61K31/502;A61K31/5025;A61K31/5365;A61K47/34;A61P1/04;A61P3/10;A61P9/00;A61P9/02;A61P9/10;A61P13/12;A61P15/00;A61P17/00;A61P19/02;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/04;A61P25/16;A61P25/28;A61P35/00;A61P37/04;A61P43/00;C07D209/80;C07D237/32;C07D471/04;C07D491/052;C07D491/06;C07D495/04;C07D495/06;C07D498/06;C07D521/00;(IPC1-7):C07D491/04;C07D498/04;A61K31/47;A61K31/50 主分类号 C07D237/26
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