| 摘要 |
The invention concerns a novel human polypeptide defensin, homologous of HNP-4, its genomic DNA and DNAc, vectors, cells transformed by said vectors, the use of said polypeptide as antibiotic, cytotoxic, repairing and endocrine regulating agent or as pesticide as well as cosmetic or pharmaceutical compositions for treating microbial infections, in particular bacterial, fungal, and viral, or parasitic, cancers, inflammation and immunodeficiency. The invention also concerns diagnostic methods and kits for determining a microbial or parasitic infection and an inflammation, or for detecting predisposition to immunodeficiency or cancerous diseases.
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