摘要 |
Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R<a> is a group of formula (i), in which P<1> is phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur; or R<a> is a group of formula (ii); L is a group of formula -Y-C(=V)-DG-, in which Y is -NH-, NR<5> where R<5> is C1-6alkyl, or Y is -CH2- or -O-; V is oxygen or sulphur; D is nitrogen, carbon or a CH group, G is hydrogen or C1-6alkyl providing that D is nitrogen or a CH group, or G together with R<b1> forms a group W where W is (CR<16>R<17>)t where t is 2, 3 or 4 and R<16> and R<17> are independently hydrogen or C1-6alkyl or W is (CR<16>R<17>)u-J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR<16>=CR<17>, CR<16>=N, =CR<16>O, =CR<16>S or =CR<16>-NR<17>; B is CH2, oxygen, S(O)p where p is 0, 1 or 2, NR<6> where R6 is hydrogen or C1-6alkyl or B is CR<7>=CR<8> where R<7> and R<8> are independently hydrogen or C1-6alkyl; R<c> and R<d> are independently hydrogen or C1-6alkyl; R<y> is a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or R<y> is a group of formula -NR<e>R<f> in which R<e> and R<f> are independently hydrogen, C1-6alkyl or aralkyl; R<b1> and R<b2> are independently hydrogen, halogen, hydroxy, C1-6alkyl, trifluoromethyl, C1-6alkoxy or aryl, or R<b1> together with G forms a group W as defined above; and n is 0, 1, 2, 3 or 4. |
申请人 |
SMITHKLINE BEECHAM PLC;GASTER, LARAMIE, MARY;WYMAN, PAUL, ADRIAN |
发明人 |
GASTER, LARAMIE, MARY;WYMAN, PAUL, ADRIAN |