USE OF POLYCYCLIC STEROID COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF CYSTIC KIDNEY DISEASES, VASCULAR INFARCTION, UREMIA AND RELATED CONDITIONS

摘要

In accordance with the present invention, there are provided methods for the treatment of cystic renal diseases, vascular infarction, catabolic and growth consequences of uremia and other related indications in mammals, employing members of a defined class of polycyclic compounds as the active agent. In accordance with another embodiment of the present invention, it has been discovered that these compounds are effective agents for the treatment of renal dysplasias and/or renal hypoplasias in mammals. In accordance with yet another embodiment of the present invention, it has been discovered that these compounds are effective agents for enhancing glomerular development in mammals. In accordance with still another embodiment of the present invention, it has been discovered that these compounds are effective agents for enhancing kidney development in mammals suffering from chronic organ injury. In accordance with a further embodiment of the present invention, it has been discovered that these compounds are effective agents for protecting kidneys from the ongoing toxicity of treatment with steroid hormones. In accordance with a still further embodiment of the present invention, it has been discovered that these compounds are effective agents for maintaining substantially normal growth in neonates, pre-pubescent and pubertal mammals exposed to high dose steroid hormone therapy and improves the poor growth associated with the catabolic effects of chronic disease or uremia in these mammals. In accordance with yet a further embodiment of the present invention, it has been discovered that these compounds prevent or treat organ vascular infarction in mammals.