| 摘要 |
FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to derivatives of 7-, 8-, 9-(substituted)-6-demethyl-6-dehydroxy- tetracyclines of the formula (I) <EMI ID=0.530 HE=27 WI=54 TI=CHI> where X - halogen; R and R are similar or distinct and mean H, NH<SB>2</SB>, halogen, NR<SP>2</SP>R and when R and R is NR<SP>2</SP>R and R is H then R - methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methyl- propyl, 1,1-dimethylethyl; when R - methyl, ethyl then R is methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1-methyl- propyl, 2-methylpropyl; when R is n-propyl then R is n-propyl, 1-methylethyl, n-butyl, 1-methylpropyl, 2-methyl- -propyl; when R is 1-methylethyl then R is n-butyl, 1-methylpropyl, 2-methylpropyl; when R is n-butyl then R is n-butyl, 1-methylpropyl, 2-methylpropyl; when R is 1-methylpropyl then R is 2-methylpropyl; when R and R are NR<SP>2</SP>R and R - H then R is -CO-R where R - H, NH<SB>2</SB>, mono-(C<SB>1</SB>-C<SB>6</SB>)-alkylamino-groups, diastereoisomers and enantiomers of mono - (C<SB>1</SB>-C<SB>6</SB>) - alkylamino - group; or R is di-(C<SB>1</SB>-C<SB>6</SB>)-alkylamino-group. Compounds are used as a pharmaceutical composition showing antibacterial activity. EFFECT: improved method of synthesis, enhanced effectiveness. 7 cl, 3 dwg, 3 tbl, 49 ex
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