Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors

摘要

Carboxylic acid derivatives (I) and their salts and enantiomers are new. Carboxylic acid derivatives of formula (I) and their salts and enantiomers are new. R = tetrazole or COR1; R1 = OR7, 3-8C cycloalkyl, 1-8C alkyl, optionally substituted phenyl or benzyl, 3-6C alkenyl or optionally substituted 3-6C alkynyl; R7 = H, alkali or alkaline earth metal cation or organic ammonium ion; R2, R3 = H, OH, NH2, mono- or di(1-4C alkyl)amino, halo, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy or 1-4C alkylthio; or CR2+CR10 = 5-6-membered ring; X, Y = N or CH; W = N or CR10; R10 = H or 1-4C alkyl; or CR10+CR2 or CR10+CR3 = 5-6-membered alkylene or alkenylene ring (optionally substituted and in which one or more of the methylene groups may be replaced by O, S, NH or N-(1-4C alkyl)); R4, R5 = optionally substituted phenyl or naphthyl (bound via a direct bond, methylene, ethylene, ethenylene, O, S, SO2, NH or N-alkyl) or optionally substituted 3-8C cycloalkyl; R6 = 3-8C cycloalkyl, phenyl, naphthyl or 5-6-membered heteroaromatic group containing 1-3 N atoms and/or an S or O atom (all optionally substituted); Z = O or S; B = 2-4C alkylene; Het = heterocyclic group of formula (i) or (ii); T = O, S or NR8; and R8 = 1-6C alkyl.