| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of perhydroisoindole of the general formula (I) <EMI ID=0.532 HE=27 WI=51 TI=CHI> where R - phenyl; R<SB>1</SB> - phenyl possibly substituted with alkoxy-, hydroxy-, dialkylamino-radicals, or naphthyl, indenyl, thienyl, benzo[a] thienyl or indolyl possibly substituted with halogen, alkoxy-group, alkyl; R<SB>2</SB> - hydrogen, hydroxyl, alkyl, amino- -radicals; R<SB>3</SB> - phenyl possibly substituted at position 2 with C<SB>1</SB>-C<SB>2</SB>-alkyl, C<SB>1</SB>-C<SB>2</SB>-alkoxyl; R<SB>4</SB> - fluorine, hydroxyl; R<SB>5</SB> - hydrogen or R<SB>4</SB> and R<SB>5</SB> are hydroxyl, or R<SB>4</SB> together with R<SB>5</SB> forms a bond being alkyl radicals can be direct or branched and have 1-4 carbon atoms, and their stereoisomeric forms also. Synthesized compounds are used as a pharmaceutical composition that acts as an antagonist of substance P. EFFECT: improved method of synthesis. 7 cl, 1 tbl, 40 ex
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