Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors

摘要

PCT No. PCT/GB93/02394 Sec. 371 Date May 17, 1995 Sec. 102(e) Date May 17, 1995 PCT Filed Nov. 22, 1993 PCT Pub. No. WO94/12631 PCT Pub. Date Jun. 9, 1994There is marked over-expression of multiple spliced variants of the CD44 gene in tumor compared to counterpart normal tissue. This observation forms the basis of a method of diagnosing neoplasia by analysis of a sample of body tissue or body fluid or waste product. A new exon 6 of 129 bp has been located and sequenced. Antibodies specific to the exon have been prepared and are claimed as new compounds suitable for use in the detection of CD44 proteins and for the in vivo imaging and therapy of tumors.