Cell cycle-regulating proteins

摘要

A DNA containing a base sequence encoding the amino acid sequence represented by SEQ ID NO:2 in the Sequence Listing, a base sequence encoding a protein having an amino acid sequence derived from the above amino acid sequence of SEQ ID NO:2 by substitution, deletion or addition of a part thereof and having the activity of regulating cell cycle, or a base sequence hybridizable therewith; a recombinant vector containing this DNA; a transformant constructed by using this vector; a process for producing AIM-1 with the use of the above DNA; a recombinant AIM-1 protein obtained by this process; an oligonucleotide or a peptide nucleic acid hybridizable specifically with a base sequence encoding the AIM-1 protein; an antibody recognizing AIM-1; remedies for diseases in association with abnormal proliferation of cells which contain AIM-1 protein inhibitors; and a method for screening substances having a serine-threeonine kinase inhibitory activity with the use of the AIM-1 gene or the AIM-1 protein.