发明名称 |
Synthesis of clasto-lactacystin beta-lactone and analogs thereof |
摘要 |
The present invention is directed to an improved synthesis of clasto-lactacystin- beta -lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin- beta -lactones, and analogs thereof and their use as proteosome inhibitors. |
申请公布号 |
AU8906298(A) |
申请公布日期 |
1999.03.08 |
申请号 |
AU19980089062 |
申请日期 |
1998.08.14 |
申请人 |
FRANCOIS SOUCY;LOUIS PLAMONDON;MARK BEHNKE;WILLIAM ROUSH |
发明人 |
FRANCOIS SOUCY;LOUIS PLAMONDON;MARK BEHNKE;WILLIAM ROUSH |
分类号 |
C07D491/044;A61K31/4015;A61K31/407;A61K31/421;A61P9/10;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07B61/00;C07C69/675;C07C231/10;C07C231/14;C07C233/82;C07C233/83;C07C235/80;C07C237/06;C07C247/04;C07D207/28;C07D263/16;C07D491/04 |
主分类号 |
C07D491/044 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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