| 发明名称 |
PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
| 摘要 |
The present invention is directed to pyrrolidine and piperidine compounds of formula (I), (wherein R<1>, R<2>, R<3>, R<4a>, R<4b>, R<4c>, R<4d>, R<4e>, R<4f>, R<4g>, R<4h>, m, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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| 申请公布号 |
WO9909984(A1) |
申请公布日期 |
1999.03.04 |
| 申请号 |
WO1998US17755 |
申请日期 |
1998.08.27 |
| 申请人 |
MERCK & CO., INC.;BUDHU, RICHARD, J.;HALE, JEFFREY, J.;HOLSON, EDWARD;LYNCH, CHRISTOPHER;MACCOSS, MALCOLM;MILLS, SANDER, G.;BERK, SCOTT, C.;WILLOUGHBY, CHRISTOPHER, A. |
发明人 |
BUDHU, RICHARD, J.;HALE, JEFFREY, J.;HOLSON, EDWARD;LYNCH, CHRISTOPHER;MACCOSS, MALCOLM;MILLS, SANDER, G.;BERK, SCOTT, C.;WILLOUGHBY, CHRISTOPHER, A. |
| 分类号 |
C07D217/02;A61K31/40;A61K31/435;A61K31/438;A61K31/4427;A61K31/443;A61K31/4433;A61K31/451;A61K31/454;A61K31/4545;A61K31/47;A61K31/4709;A61K31/472;A61K31/4725;A61K31/496;A61K31/55;A61P29/00;A61P31/18;A61P37/00;C07D207/09;C07D211/14;C07D211/70;C07D211/96;C07D223/02;C07D223/16;C07D401/06;C07D401/14;C07D403/06;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D495/10;(IPC1-7):A61K31/47;A61K31/445;A61K31/495;C07D211/68 |
主分类号 |
C07D217/02 |
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