AZETIDINONE DERIVATIVES AS .BETA.-LACTAMASE INHIBITORS

摘要

Novel 2-oxo-1-azetidine sulfonic acid derivatives which are potent inhibitors of bacterial .beta.-lactamases, particularly against class C .beta.lactamases. Pharmaceutical compositions contain these compounds, and optionally also a .beta.-lactam antibiotic. The compounds and compositions can be used to inhibit .beta.-lactamase inactivation, and for the treatment of bacterial infections.