发明名称 |
PHARMACEUTICAL COMPOSITION FOR COMBINATION OF PIPERIDINOALKANOL-DECONGESTANT |
摘要 |
The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising: (a) a first discrete zone made with Formulation (A) which comprises a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18 % to about 39 % by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of: (i) carnauba wax in an amount of about 59 % to about 81 % by weight of Formulation (A); and (ii) a suitable antiadherent in an amount of about 0.25 % to about 2.00 % by weight of Formulation (A); wherein said first carrier base material provides a sustained release of the sympathomimetic drug; and (b) a second discrete zone made with Formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15 % to about 30 % by weight of Formulation (B) and a second carrier base material, the second carrier base comprisisng a mixture of: (i) a cellulose diluent in an amount of about 27 % to about 73 % by weight of Formulation (B); (ii) pregelatinized starch in an amount of about 15 % to about 30 % by weight of Formulation (B); (iii) a suitable disintegrant in an amount of about 0.25 % to about 6.00 % by weight of Formulation (B); and (iv) a suitable lubricant in an amount of about 0.25 % to about 2.00 % by weight of Formulation (B); wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof. |
申请公布号 |
WO9909957(A1) |
申请公布日期 |
1999.03.04 |
申请号 |
WO1998US15237 |
申请日期 |
1998.07.21 |
申请人 |
HOECHST MARION ROUSSEL, INC. |
发明人 |
MACLAREN, DAVID, D.;LEFLER, JOHN, R.;MINISH, SHARON, K. |
分类号 |
A61K9/20;A61K9/22;A61K9/24;A61K31/445;A61K45/00;A61K45/06;A61K47/04;A61K47/12;A61K47/38;A61K47/44;A61P11/02;A61P11/08;A61P37/08;A61P43/00 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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