The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In paricular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
申请公布号
WO9910364(A1)
申请公布日期
1999.03.04
申请号
WO1998US17710
申请日期
1998.08.27
申请人
HUMAN GENOME SCIENCES, INC.;RUBEN, STEVEN, M.;DUAN, ROXANNE